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| Antonio Banderas | Robert Ledgard | |
| Elena Anaya | Vera Cruz | |
| Marisa Paredes | Marilia | |
| Jan Cornet | Vicente | |
| Roberto Alamo | Zeca | |
| Eduard Fernandez | Fulgencio | |
| Jose Luis Gomez | Presidente del Instituto de Biotecnología | |
| Blanca Suarez | Norma Ledgard | |
| Susi Sánchez | Madre de Vicente | |
| Bárbara Lennie | Cristina | |
| Fernando Cayo | Médico | |
| Chema Ruiz | Policía | |
| Buika | Cantante | |
| Ana Mena | Norma joven | |
| Teresa Manresa | Casilda Efraiz | |
| Fernando Iglesias | ||
| Agustín Almodóvar | Agustín | |
| Miguel Almodóvar | Hijo de Agustín | |
| Marta R. Mahou | Profesora de Yoga en TV | |
| Guillermo Carbajo | Amigos | |
| Violaine Estérez | Colega del Dr. Ledgard | |
| Sheyla Fariña | Amigos | |
| Esther García | Presentadora | |
| Iván González Lewis | Músico | |
| Carmen Machi | Wedding Guest | 
| Director | 
              
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| Producer | 
              Esther Garcia
               Agustin Almodovar  | 
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| Writer | 
              Pedro Almodóvar
               Agustin Almodovar Thierry Jonquet  | 
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| Cinematography | 
              José Luis Alcaine
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| Music | 
              Alberto Iglesias
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             A brilliant plastic surgeon creates a synthetic skin that withstands any kind of damage. His guinea pig: a mysterious and volatile woman who holds the key to his obsession.  | 
        
            
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