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| Ian McKellen | Bill Kraus | |
| Alan Alda | Dr. Robert Gallo | |
| Glenne Headly | Dr. Mary Guinan | |
| Lily Tomlin | Dr. Selma Dritz | |
| Richard Gere | The Choreographer | |
| Anjelica Huston | Dr. Betsy Reisz | |
| Nathalie Baye | Dr. Françoise Barre | |
| Swoosie Kurtz | Mrs. Johnstone | |
| Steve Martin | The Brother | |
| B.D. Wong | Kico Govantes | |
| Christian Clemenson | Dr. Dale Lawrence | |
| Saul Rubinek | Dr. Jim Curran | |
| Phil Collins | Eddie Papasano | |
| David Dukes | Dr. Mervyn Silverman | |
| David Grant | Dennis Seeley | |
| Matthew Modine | Dr. Don Francis | |
| Ronald Guttman | Dr. Jean-Claude Chermann | |
| Richard Masur | William W. Darrow, PhD | |
| Bud Cort | Antique shop owner | |
| Patrick Bauchau | Dr. Luc Montagnier | |
| Charles Martin Smith | Dr. Harold Jaffe | |
| David Clennon | Mr. Johnstone | |
| Alex Courtney | Dr. Mika Popovic | |
| David Marshall Grant | Dennis Seeley | |
| Ken Jenkins | Dr. Dennis Donohue | |
| Richard Jenkins | Dr. Marc Conant | |
| Tcheky Karyo | Dr. Willy Rozenbaum | |
| Jack Laufer | Brian McDonough | |
| Donal Logue | Bobbi Campbell | |
| Richard Masur | William W. Darrow / PhD | |
| Dakin Matthews | Congressman Phil Burton |
| Director/Choreographer |
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| Producer | Sarah Pillsbury
Midge Sanford Marcia Basichis Cynthia Fitzpatrick |
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| Writer/Composer |
Arnold Schulman
Randy Shilts |
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| Cinematography |
Paul Elliott
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| Music |
Carter Burwell
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The story of the discovery of the AIDS epidemic and the political infighting of the scientific community hampering the early fight with it. |
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