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| Kurt Russell | Drew Stephens | |
| Fred Ward | Morgan | |
| David Strathairn | Wesley | |
| James Rebhorn | Los Alamos Doctor | |
| Cher | Dolly Pelliker | |
| Meryl Streep | Karen Silkwood | |
| M. Emmet Walsh | Walt Yarborough | |
| Ron Silver | Paul Stone | |
| J.C. Quinn | Curtis Schultz | |
| Craig T. Nelson | Winston | |
| Diana Scarwid | Angela | |
| Bruce McGill | Mace Hurley | |
| Charles Hallahan | Earl Lapin | |
| Henderson Forsythe | Quincy Bissell | |
| Josef Sommer | Max Richter | |
| Sudie Bond | Thelma Rice | |
| Graham Jarvis | Doctor at Union Meeting | |
| E. Katherine Kerr | Gilda Schultz | |
| Cherilyn Sarkisian | Dolly Pelliker | |
| Kent Broadhurst | Carl | |
| Richard Hamilton | Georgie | |
| Les Lannom | Jimmy | |
| Ray Baker | Pete Dawson | |
| Michael Bond | 2nd Los Alamos Doctor | |
| Bill Cobbs | Man in Lunchroom | |
| Norman Colvin | Zachary |
| Director/Choreographer |
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| Producer | Mike Nichols
Michael Hausman Larry Cano |
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| Writer/Composer |
Nora Ephron
Alice Arlen |
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| Cinematography |
Miroslav Ondricek
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| Music |
Georges Delerue
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The story of Karen Silkwood, a metallurgy worker at a plutonium processing plant who was purposefully contaminated, psychologically tortured and possibly murdered to prevent her from exposing blatant worker safety violations at the plant. |
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